Journal of In Silico & In Vitro Pharmacology

Synthesis and In vitro Pharmacological Evaluation of Novel Variants of 4-Pyridyl Compound and Pyridyl Thiazole Substituents

Background: Thiazoles are one of the most studied 5- membered aromatic heterocyclic. Many natural and synthetic thiazoles, as well as their derivatives, exhibited biological activity. Thiazole derivatives have antibacterial action against a variety of bacteria and diseases due to their unique characteristics. Because of its immense biological significance, scientists are working hard to develop novel biologically active thiazole compounds.

Method: In the present study the synthesis of some derivatives of the 2-pyridyl/3-pyridyl and 4-pyridyl substituent at C-2 and the aryl substituent at C-2 (scheme 1) design and the desired target molecules 2a-2g, 3a-3g and 4a-4g were synthesized via the classic Hantzsch thiazole synthesis.

Results: The synthesized compounds were confirmed on the basis of IR, 1H-NMR and mass analyses. The newly synthesized compounds were evaluated for their antimicrobial, anti-candidal and anti-mycobacterial activity by S. aureus and E. coli; anticandial activity of test compound was assessed against Candida albicans and Mycobacterium smegmatis for anti-mycobacterial activity.

Conclusion: The biological importance of pyridyl-thiazole derivatives is reported here in the clubbed pyridyl-thiazole derivatives as possible antimycobacterial drugs, as part of our hunt for new antitubercular medicines.

Author(s): Hemant Chikhale*, Sharma Lokesh P, Bhawsar Swati P, Suryawanshi Manjusha B, Patil Sachin V and Patil Amar A

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