Journal of In Silico & In Vitro Pharmacology

DTAB Catalysed Azadirachta indica Oil/ Water Bio-Emulsion for Enhancing the Antioxidant Efficacy of Ceftriaxone

For examining the improvement in antioxidant aptitude of Ceftriaxone, an antibiotic drug, through encapsulation, the bio-emulsion using Neem oil (Azadirachta indica) with aqueous Dodecyl Trimethyl Ammonium Bromide (DTAB) have been framed. The prepared emulsions have been characterized with physicochemical properties (PCPs) where alterations in PCPs of pure and drug encapsulated emulsions were attributed for distinguishing them. The formulations have been screened for radical scavenging activity (RSA) with free radical 2, 2-diphenyl-1-picrylhydrazyl through spectrophotometric and physicochemical methods. With DPPH (2,2-diphenyl-1- picrylhydrazyl) assay, the antioxidant potential of pure drug and with emulsion have been carried out where the formulation showed increment in such activity of ceftriaxone. First time the scavenging activity is examined with PCPs along with DPPH assay where reduction in values of surface tension, viscosity and potential are attributed for the radical scavenging activity, similar to DPPH assay. The reduced values of such properties of ceftriaxone encapsulated emulsions have quantitatively confirmed the improvement of antioxidant activity of ceftriaxone.

Author(s):

Ameta RK ,Sangani CB, Pansuriya B, Mali M, Kataria P, Patel M and Kawad M

Abstract | Full-Text | PDF

Share this