Journal of In Silico & In Vitro Pharmacology

Abstract

Carbon dots (C-Dots) with diameter smaller than 10 nm have recently triggered great attention in the research of materials science and engineering due to their unique properties. Their potential applications have been explored in dielectric materials, optical sensing, and biomedical engineering. In this study, water soluble C-Dots were prepared from oxidizing carbon powders by a mixture of sulfuric acid and nitric acid. These C-Dots were characterized by spectroscopy (UV-Vis, fluorescence, FTIR, and XPS) and microscopy (AFM and TEM). C-Dots have been studied for dielectric properties and biomedical applications. Studies have showed that C-Dots based hybrids can be used as excellent electrode materials for capacitors. With C-Dots doping to a ferroelectric liquid crystal structure, remarkable enhancements were found in terms of switching response, spontaneous polarization and dielectric constant. Regarding the biomedical applications of C-Dots, our study showed that C-Dots could inhibit protein fibrillation, such as insulin and amyloid beta 40/42. Therefore, they could be potentially used as a drug to treat diseases associated with protein fibrillation. After conjugation with a plasma protein transferrin, these C-Dots could enter the central nervous system.

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