Journal of In Silico & In Vitro Pharmacology

Introduction

We strive to bring together a large quantity of scientific and technical knowledge from increasingly crossing interdisciplinary fields of research in this article to stress the critical role that pharmacologists can play in the development of curative therapies. The needs for regenerative pharmacology development will be substantially higher. Indeed, the challenges of regenerative pharmacology, or curative therapeutics, will in many cases necessitate complex mixtures of compounds (i.e., growth factors such as Fibroblast Growth Factor (FGF), Epidermal Growth Factor (EGF), platelet-derived growth factor, Nerve Growth Factor (NGF), Bone Morphogenic Proteins (BMPs), and others) for tissue/organ function restoration. One of the main goals is to show how the rigorous use of pharmaceutical sciences will speed up the success of such an effort. The complicated pharmacology of mammalian wound healing and functional regeneration is still unknown to us. Correction of this knowledge gap will necessitate a global multidisciplinary, collaborative effort to promote debates at the intersections of pharmacology, biomaterials, biomedical/tissue engineering, nanotechnology, stem cell and developmental biology, and other fields.

The creation of increasingly sophisticated functionalized biomaterials, as well as innovative drug delivery systems, has resulted from advances in research at the interface of biology, chemistry, and materials science. A thorough examination of the most recent functionalized biomaterials and contemporary drug delivery methods alone would necessitate a lengthy paper. Furthermore, existing medication delivery systems and technologies include a diverse range of largely applicationspecific technology. The prospective applications of the present technology discussed here, on the other hand, indicate to future possibilities.

Biomaterials in Regenerative Pharmacology

The field of biomaterials has progressed from the usage of inert materials to the development of bioactive materials that can integrate into host tissues. Modifications of biomaterials to enable extremely selective cell targeting-as in the case of nano particulate delivery systems-to surface modification of implantable materials to enhance cell adhesion and tissue integration are all examples of functionalized biomaterials. This focuses on the former; however the potential applications of these two kinds of biomaterials in regenerative medicine are deeply intertwined.

Biomaterials and Scaffolding Systems

Biomaterials are an important part of the tissue engineering paradigm, since they serve as a temporary matrix for cell infiltration and as delivery depots for therapeutic medicines. Fabrication techniques have been employed to create scaffolds from a range of biomaterials, and they have played an important role in defining these parameters for more effective scaffolds for many applications. Each technique has its own set of benefits and drawbacks, but in general, greater degrees of architectural organisation are surrendered in favour of production simplicity and speed.

Conclusion

Since we initially attempted to bring the new subject of regenerative pharmacology to the attention of pharmacologists, there has been an explosion of information and a simultaneous growth in technical development. Our main goal was to present enough detail from each of the major intersecting disciplines of research to stress the importance of multidisciplinary collaboration, and we hope that one of the outcomes of this report will be that it will prompt the necessary discussions among all stakeholders.