Journal of In Silico & In Vitro Pharmacology

Severe Acute Respiratory Syndrome-Coronavirus-2 (SARS-COV-2) Inhibition and Other Antiviral Effects of Ethiopian Medicinal Plants and Their Compounds

Since the outbreak of coronavirus disease 19 (COVID-19), so many people were dying in the world. Treatment modalities have not been developed yet although repurposing of different drugs is done swiftly. None of the repurposed drugs has been approved for treating this pandemic to date. To this effect, herbal medicines are getting a lot of attention in many developing countries since they have a long history of utility to prevent and treat viral infection. Up on extending this knowledge several compounds isolated from herbs are on the pipeline of in silico studies to investigate their inhibitory effects on COVID-19. Most of them exhibited promising effects, although in vitro, in vivo, and clinical studies are needed to substantiate their therapeutic implications. This review focuses on herbal medicines of Ethiopia and their compounds potential complementary effects for the treatment of this disease and other viral infections that need prompt further investigations. Most of the medicinal plants and their compounds mentioned herein are investigated for their anti-COVID-19 activities in different molecular docking studies.

Author(s):

Yohannes Tsegyie Wondmkun*, Ousman Ahmed Mohammed

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