Journal of In Silico & In Vitro Pharmacology

Preparation and Characterization of Liposome Containing Minoxidil and Rosemary Essential Oil

Minoxidil and Rosemary essential oil have been used for several years to stimulate hair growth. Therefore, coadministration of both Minoxidil and Rosemary essential oil could enhance hair growth. The chemical/biological characteristics of liposomes, which encapsulate both hydrophobic and hydrophilic drugs, can be utilized to encapsulate the herbal and chemical drug concoction concomitantly. A thin-film hydration method was used to prepare the liposomes. The entrapment efficacy of the liposomes was determined for Minoxidil and Rosemary essential oil using UV spectrophotometry and hydrodistillation; as dictated in the European pharmacopeia. Furthermore, a dynamic light scattering (DLS) analysis was conducted to determine the particle size and zeta potential of the prepared liposome. In addition, the storage stability of the liposome was checked after 60 days. The results showed that coencapsulation of Minoxidil and Rosemary essential oil increased the encapsulation efficacy of Minoxidil while the entrapment efficacy of essential oil was not significantly influenced. In addition, according to the DLS results, the particle size and zeta potential of prepared liposomes didn’t change significantly during 60 days of storage.

Author(s):

Gita Kiaee, Hamid Akbari Javar, Bita Kiaee2and Shadi Kiaei

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