Neurodegenerative infections are named for the age-related constant and reformist loss of design and capacity of neurons. Most normal neurodegenerative infections incorporate Alzheimer's Disease (AD) and Parkinson's Disease (PD). Up until this point, no medications can be utilized to turn around the neuronal degeneration. Late advances in undeveloped cells science and innovation permit us to create explicit sorts of neurons, for example, cholinergic and dopamine neurons from undeveloped cells, with characterized culture conditions. These undifferentiated organism determined neurons have been utilized for cell substitution treatment in creature models of neurodegenerative neurons, like AD and PD. Here, I summed up late advances of immature microorganism inferred cholinergic and dopamine neurons and their applications in AD and PD.