Journal of In Silico & In Vitro Pharmacology

A Brief Journey of Tocotrienols as Anticancer Agents

The journey of tocotrienol is started when the Vitamin E was first discovered as the fertility factor. Later in the research studies vitamin E was found to be consisting of eight isomers which can be divided into two separate groups known as tocopherols and tocotrienols. The isomers share similarity in structure but differ at much levels based upon their functional or biological properties. Initially tocopherols were investigated much due to their powerful antioxidant properties. However, the other four isomers of tocotrienols were found to be consisting of anticancer properties at varying degree in vitro and in vivo. The mechanisms mediated by tocotrienols such as NFkB pathway, apoptosis, and effect on DNA polymerases are totally different to those of tocopherols.

Author(s):

Kabir I, Rahman M, Rahman K and Islam T

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