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Multilayered Controlled Released Topical Patch Containing Tetracycline for Wound Dressing

Proficient antibiotic drug delivery plays a key role in treating infections. In this article we prepared an electrospun wound dressing which releases Tetracycline in a timed and dose controlled matter for one week. In order to fabricate a wound dressing which can release Tetracycline in a longer duration and at an effective therapeutic level we designed a bilayer electrospun patch made of polyvinyl alcohol (PVA), polycaprolacton (PCL), and coated the whole system with chitosan. The SEM micrograph showed the dependent relationship of the morphology of the nanofibers on the Tetracycline concentration, and the addition of PCL electrospun layer decreased the pore size and water uptake rate. However, it was found that coating PVA/PCL bilayered electrospun sheet with chitosan increased the water uptake rate, which is an important property in biomedical applications. According to the FTIR results, chemical composition of the scaffolds did not change during the fabrication process. Mechanical properties of the samples were assessed, and the results revealed that the chitosan coating improved the tensile strength of the electrospun layers. Furthermore, based on in vitro release tests, it was found that bilayered electrospun sheets coated with chitosan controlled drug release efficiently. In addition, the antibacterial tests performed in vitro showed stronger antibacterial activity on S. aureus cultures for PVA/PCL/Chitosan in comparison to uncoated samples.


Gita Kiaee, Mahbobe Etaat,Bita Kiaee,Shadi Kiaei and Hamid Akbari Javar

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