Abstract

DTAB Catalysed Azadirachta indica Oil/ Water Bio-Emulsion for Enhancing the Antioxidant Efficacy of Ceftriaxone

For examining the improvement in antioxidant aptitude of Ceftriaxone, an antibiotic drug, through encapsulation, the bio-emulsion using Neem oil (Azadirachta indica) with aqueous Dodecyl Trimethyl Ammonium Bromide (DTAB) have been framed. The prepared emulsions have been characterized with physicochemical properties (PCPs) where alterations in PCPs of pure and drug encapsulated emulsions were attributed for distinguishing them. The formulations have been screened for radical scavenging activity (RSA) with free radical 2, 2-diphenyl-1-picrylhydrazyl through spectrophotometric and physicochemical methods. With DPPH (2,2-diphenyl-1- picrylhydrazyl) assay, the antioxidant potential of pure drug and with emulsion have been carried out where the formulation showed increment in such activity of ceftriaxone. First time the scavenging activity is examined with PCPs along with DPPH assay where reduction in values of surface tension, viscosity and potential are attributed for the radical scavenging activity, similar to DPPH assay. The reduced values of such properties of ceftriaxone encapsulated emulsions have quantitatively confirmed the improvement of antioxidant activity of ceftriaxone.


Author(s):

Ameta RK ,Sangani CB, Pansuriya B, Mali M, Kataria P, Patel M and Kawad M



Abstract | Full-Text | PDF

Share this  Facebook  Twitter  LinkedIn  Google+

Recommended Conferences

  • 16th International Conference and Exhibition on Pharmaceutics & Novel Drug Delivery Systems
    March 19-21, 2018 Berlin, Germany
  • 4th International Conference on Antibiotics: R&D, B2B April 20-21, 2018 Las Vegas, Nevada, USA
    April 20-21, 2018 Las Vegas, Nevada, USA
  • 1th European Biosimilars Congress April 26-27, 2018 Rome, Italy
    April 26-27, 2018 Rome, Italy
  • 15th Annual European Pharma Congress May 07-09, 2018 Frankfurt, Germany
    May 07-09, 2018 Frankfurt, Germany
Flyer image

Abstracted/Indexed in

  • Google Scholar
  • WorldCat
  • Publons